Epigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers
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چکیده
منابع مشابه
High expression of microRNA-454 is associated with poor prognosis in triple-negative breast cancer
MicroRNA-454 (miR-454) has been reported to play an oncogenic or tumor suppressor role in most cancers. However, the clinical relevance of miR-454 in breast cancer remains unclear. We examined the expression of miR-454 in a tissue microarray containing 534 breast cancer specimens from female patients at Fudan University Shanghai Cancer Center using in situ hybridization (ISH). Of these, 250 pat...
متن کاملAccumulation of p62 is associated with poor prognosis in patients with triple-negative breast cancer
BACKGROUND Triple-negative breast cancer (TNBC) is associated with poor prognosis. There is an urgent need for elucidation of novel targets for TNBC therapy and to improve the prognosis of patients. The aim of this study was to evaluate the prognostic value of p62 expression in TNBC. METHODS AND RESULTS Expression of p62 in tissue microarray was evaluated by immunohistochemistry in 163 patien...
متن کاملPatients with Concordant Triple-Negative Phenotype between Primary Breast Cancers and Corresponding Metastases Have Poor Prognosis
PURPOSE We investigated the prognostic impact of discordance between the receptor status of primary breast cancers and corresponding metastases. METHODS A total 144 patients with breast cancer and distant metastasis were investigated. The estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) status of primary tumor and corresponding metastases...
متن کاملCD24 Overexpression Is Associated with Poor Prognosis in Luminal A and Triple-Negative Breast Cancer
CD24 is associated with unfavourable prognoses in various cancers, but the prevalence of CD24 expression and its influence on clinical outcome in subtypes of breast cancers remain unclear. CD24 expression was analyzed by immunohistochemistry in 747 breast cancer tissues, and DNA methylation and histone modification status in the promoter region of CD24 were assessed using bisulfite sequencing a...
متن کاملCIP4 promotes metastasis in triple-negative breast cancer and is associated with poor patient prognosis
Signaling via epidermal growth factor receptor (EGFR) and Src kinase pathways promote triple-negative breast cancer (TNBC) cell invasion and tumor metastasis. Here, we address the role of Cdc42-interacting protein-4 (CIP4) in TNBC metastasis in vivo, and profile CIP4 expression in human breast cancer patients. In human TNBC cells, CIP4 knock-down (KD) led to less sustained activation of Erk kin...
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ژورنال
عنوان ژورنال: Breast Cancer Research
سال: 2016
ISSN: 1465-542X
DOI: 10.1186/s13058-016-0672-x